Kama (Fate) vs The Great Holy Spirit: who would win?

The Great Holy Spirit favored — Slight edge (~55%)

Kama (Fate) · Nasuverse · Beast III/Lapse

Tier

1-C

Attack Potency

Complex Multiverse Level

Speed

Immeasurable, up to Omnipresent

Durability

Complex Multiverse Level

The Great Holy Spirit · Tensei Shitara Slime Datta Ken · Base

Tier

1-C

Attack Potency

Complex Multiverse Level

Speed

Omnipresent

Durability

Complex Multiverse Level

A heuristic estimate from normalized VS Battles Wiki stats: tier, attack potency, speed and durability.