Matango Spawn vs Mega-Megamind: who would win?

Mega-Megamind favored — Slight edge (~55%)

Matango Spawn · Godzilla · Base

Tier

8-A

Attack Potency

Multi-City Block Level+

Speed

Immobile, up to Supersonic+

Durability

Multi-City Block Level+

Mega-Megamind · Megamind · Base

Tier

8-A, up to HIGH 6-C

Attack Potency

Multi-City Block Level+, up to Large Island Level

Speed

Hypersonic, up to Massively Hypersonic

Durability

Multi-City Block Level+, up to Large Island Level

A heuristic estimate from normalized VS Battles Wiki stats: tier, attack potency, speed and durability.