The Great Holy Spirit vs Lucemon: who would win?

The Great Holy Spirit favored — Slight edge (~55%)

The Great Holy Spirit · Tensei Shitara Slime Datta Ken · Base

Tier

1-C

Attack Potency

Complex Multiverse Level

Speed

Omnipresent

Durability

Complex Multiverse Level

Lucemon · Digimon · Lucemon

Tier

1-C

Attack Potency

Complex Multiverse Level

Speed

Immeasurable, up to Omnipresent

Durability

Complex Multiverse Level

A heuristic estimate from normalized VS Battles Wiki stats: tier, attack potency, speed and durability.