Eli Morrow (Marvel Cinematic Universe) vs Isshin: who would win?

Isshin favored — Favored (~65%)

Eli Morrow (Marvel Cinematic Universe) · Marvel · With Preparation Time/Plutonium Bomb

Tier
7-A
Attack Potency
Mountain Level+
Speed
Average Human, up to Athletic Human
Durability
Human Level

Isshin · Undead Unluck · Base

Tier
HIGH 7-A
Attack Potency
Large Mountain Level
Speed
High Hypersonic, up to Massively Hypersonic+
Durability
Large Mountain Level

A heuristic estimate from normalized VS Battles Wiki stats: tier, attack potency, speed and durability.